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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359
EISSN: 0019-5359
Vol. 64, No. 12, 2010, pp. 564-576
Bioline Code: ms10007
Full paper language: English
Document type: Special Article
Document available free of charge

Indian Journal of Medical Sciences, Vol. 64, No. 12, 2010, pp. 564-576

 en Cardiac biomarkers in the diagnosis, prognosis and management of coronary artery disease: A primer for internists
Chopra, Vineet & Eagle, Kim A.


Initially coined in 1989, biomarkers have become a cornerstone of modern cardiovascular medicine. The past decade has borne witness to the rapid transition of cardiac biomarkers from bench to bedside in the management of patients with coronary artery disease. The implementation of cardiac biomarkers has transformed the internists′ approach to cardiovascular patients. This article reviews several cardiac biomarkers in the context of diagnosis, prognosis, risk-assessment and management of patients at risk of adverse cardiovascular outcomes. Biomarkers are presented according to their relevant role in the atherosclerotic cascade, a pathologic classification of particular value for internists, as it defines the role of these agents in the pathogenesis of heart disease. Where pertinent, limitations of cardiac biomarkers are discussed, thus allowing the discerning practitioner to remain cognizant of situations that may lead to spurious marker elevation or suppression. The review concludes with highlights on novel avenues of biomarker research that promise an exciting future for these entities.

Biomarker, brain natiuretic peptide, coronary artery disease, C-reactive protein, homocysteine

© Copyright 2010 Indian Journal of Medical Sciences.
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