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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 16, No. 3, 2006, pp. 289-294
Bioline Code: pe06038
Full paper language: Farsi
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 16, No. 3, 2006, pp. 289-294

 en Prevalence of different etiology in neonatal cholestasis
Najafi, M; Khodadad, A; Khatami, GhR; Farahmand, F; Falahi, GhH & Motamed, F


Background: Cholestasis in infants has many causes. Idiopathic neonatal hepatitis and biliary atresia are the most common causes. The clinical presentations of cholestasis in infancy caused by neonatal hepatitis and biliary atresia are very similar. Diagnosis may be difficult on many occasions. The surgical treatment for biliary atresia should be performed as early as possible. Some of the other causes that need urgent treatment are galactosemia, sepsis and hypothyroidism.
Methods: In this descriptive cross sectional study we reviewed the 203 patients with cholestasis. In all of them TORCH and metabolic disease were investigated and sonography, PIPIDA scan and liver biopsy were done.
Findings: Idiopathic neonatal hepatitis (46.3%) and biliary atresia (30.5%), were the two main causes of cholestasis. After these metabolic diseases (13.7%) were in the third position.
Conclusion: The approach to different causes of cholestasis should first be in the differentiation between idiopathic neonatal hepatitis and biliary atresia. After that treatable causes (metabolic, sepsis) must be considered.

Neonatal cholestasis , Idiopathic neonatal hepatitis , biliary atresia , direct hyperbilirobinemia , Infant

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