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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 18, No. 3, 2008, pp. 277-280
Bioline Code: pe08044
Full paper language: English
Document type: Case Report
Document available free of charge

Iranian Journal of Pediatrics, Vol. 18, No. 3, 2008, pp. 277-280

 en Severe Neonatal Hypercalcemia due to Primary Hyperparathyroidism; A Case Report
Shiva, Siamak; Nikzad, Alireza; Aslanabadi, Saeid; Montazeri, Vahid & Nikzad, Mohammad-Reza


Background: Neonatal primary hyperparathyroidism (NPHP) is a rare disease characterized by marked hypercalcemia, diffuse parathyroid hyperplasia and skeletal demineralization. These patients have symptoms of chronic hypercalcemia such as failure to thrive, irritability, abdominal pain and anorexia. It is often fatal unless parathyroidectomy is performed.Treatment with drugs usually is inadequate and often results in chronic hypercalcemia and death.
Case presentation: A 10-day-old, 2.9 kg male newborn was hospitalized for anorexia, poor feeding, cyanosis, hypotonia, lethargy and severe dehydration. Diagnosis of severe hypercalcemia due to primary hyperparathyroidism was established and surgical approach selected because of failure of medical therapy to control hypercalcemia. The baby was successfully treated by total parathyroidectomy with autotransplantation.
Conclusion: Although neonatal primary hyperparathyroidism (NPHP) is a rare disease, it must be considered for differential diagnosis in neonates with severe hypercalcemia. Early diagnosis and total parathyroidectomy with autotransplantation can be life-saving.

Primary hyperparathyroidism; Neonate; Parathyroidectomy; Autotransplantation

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