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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 20, No. 2, 2010, pp. 211-215
Bioline Code: pe10030
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 20, No. 2, 2010, pp. 211-215

 en Study on efficacy of hepatitis B immunization in vaccinated beta-thalassemia children in Tehran
Sharifi, Zohreh; Milani, Saeideh & Shooshtari, Mahmood Mahmoodian


Objective: In thalassemic children, hepatitis B virus (HBV) infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran.

Methods: To assess the efficacy of immunization and determine the immune response of children with beta-thalassemia, sera of 99 children who had received three doses (10/20 μg) of recombinant HBV vaccine in months 0, 1, 6, were selected and tested for HBs-Ag, HBs-Ab and anti-HBc by enzyme linked immunosorbent assay method. Also, these sera were tested for HBV DNA using nested-PCR (polymerase chain reaction) method.

Findings: In 99 beta-thalassemic children, 89 (89.9 %) were anti-HBs positive (responders) and 10 (10.1%) anti-HBs negative (non-responders). Three cases (3.03%) were anti-HBc positive and 1(1.01%) was HBs-Ag positive. HBV DNA was not detected in any of them.

Conclusion: Our results have revealed that hepatitis B vaccine is highly immunogenic for thalassemic children and particularly well tolerated.

Beta-thalassemia; Vaccination; Immunization Hepatitis B; Iran

© Copyright 2010 Iran Journal of Pediatrics.
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