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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 23, No. 1, 2013, pp. 105-108
Bioline Code: pe13018
Full paper language: English
Document type: Case Report
Document available free of charge

Iranian Journal of Pediatrics, Vol. 23, No. 1, 2013, pp. 105-108

 en Generalized Lymphadenopathy in Infancy; a Case Report
Mamishi, Setareh; Movahedi, Zahra; Mohammadzadeh, Vahid & Sabouni, Farah


Background: Rosai-Dorfman disease (RDD) is a rare disease of histiocytic cells, a cause of benign cervical lymphadenopathy (LAP) and massive generalized lymph node enlargement in children and adults. There are also some reports on involvement of other human body organs with or without LAP.
Case Presentation: A 7-month-old infant with chief complaint of generalized massive LAP was referred to our center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and immunoreactivity study on the obtained sample by cervical lymph node biopsy.
Conclusion: RDD is not a malignant illness and lymph node enlargement most often decreases in its size happens without special treatment.

Rosai-Dorfman Disease; Generalized Lymphadenopathy; Infant; Histiocytosis

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