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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 23, No. 4, 2013, pp. 389-395
Bioline Code: pe13076
Full paper language: English
Document type: Special Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 23, No. 4, 2013, pp. 389-395

 en Familial History and Recurrence of Febrile Seizures; a Systematic Review and Meta-Analysis
Veisani, Yousef; Delpisheh, Ali & Sayehmiri, Kourosh


Objective: Febrile seizure (FS) as the most common form of seizures in childhood, affects 2-5% of all children across the world. The present study reviews available reports on FS recurrence frequency and evaluates its associated risk factors in Iran.
Methods: We searched the Persian database such as: SID, MagIran, Medlip, Irandoc, Iranmedex as well as English databases PubMed, ISI, and Scopus. Random effects models were used to calculate 95% confidence intervals. Meta regression was introduced to explore the heterogeneity between studies.
Findings: The overall FS recurrence rate was 20.9% [95% confidence interval (CI): 12.3-29.5%]. The frequency of FS simple and complex types was 69.3% (95% CI: 59.5-79.0) and 25.3% (95% CI: 19.6-31.0), respectively. A positive familial history of 28.8% (95% CI: 19.3-38.4%) was observed for childhood FS including 36.2% (95% CI: 27.3-39.6%) for the simple and 29.4% (95% CI: 23.1-33.5%) for the complex type. The heterogeneity of recurrent FS was significantly affected by sample size (P=0.026).
Conclusion: Almost one-third of FS children had a positive familial history. The increased risk of recurrence in patients with symptomatic seizures needs to be fully considered by parents, physicians, nurses and health policy makers.

Febrile seizure; Recurrence; Positive familial History; Systematic review; Meta-Analysis; Iran

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