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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 26, No. 1, 2016, pp. 1-4
Bioline Code: pe16003
Full paper language: English
Document type: Report
Document available free of charge

Iranian Journal of Pediatrics, Vol. 26, No. 1, 2016, pp. 1-4

 en Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis
Mehta, Yogesh; Shitole, Charudatta & Setia, Maninder Singh


Background: Neonates and infants with hypomagnesemia present with seizures and psychomotor delay.
Objectives: The present study evaluated the changes in magnesium (Mg) levels and factors associated with these in the first three days of life.
Materials and Methods: We monitored 50 clinically asymptomatic neonates; they were not given any magnesium supplements even if they had hypomagnesemia at baseline. The variables analysed were: serum Mg; gestational age; birth weight; length; and the ponderal index. We used random effects (RE) models for longitudinal analysis of these data.
Results: The mean standard deviation (SD) gestational age was 36.3 (3.6) weeks and the mean (SD) weight was 2604.2 (754.4) grams. About 31% of the neonates had hypomagnesemia (< 1.6 mg/dL) on day one; however, all had normal magnesium levels by day three of life (P < 0.001). At birth, after adjusting for intrauterine growth retardation status (IUGR), serum Mg levels were lower by 0.0097 mg/dL (95% CI: -0.019 to -0.0003) per 100 grams increase in weight of the neonate. After adjusting for IUGR status, the mean increase in the serum Mg levels was 0.14 mg/dL (95% confidence intervals [CI]: 0.10 to 0.18) per day. The per-day increase in magnesium levels was significantly higher in low birth weight babies (0.10, 95% CI: 0.01 to 0.18) compared with normal birth weight babies.
Conclusions: Asymptomatic neonates may have a high prevalence of hypomagnesemia; however, the levels become normal without any magnesium supplementation. Even though regular monitoring of magnesium levels is useful, no supplements are required - particularly in clinically asymptomatic neonates.

Magnesium, Supplementation, Hypomagnesemia

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