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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 26, No. 1, 2016, pp. 1-5
Bioline Code: pe16009
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 26, No. 1, 2016, pp. 1-5

 en Saccharomyces Boulardii check for this species in other resources in Helicobacter Pylori check for this species in other resources Eradication in Children: A Randomized Trial From Iran
Namkin, Kokab; Zardast, Mahmood & Basirinejad, Fatemeh


Background: Helicobacter Pylori check for this species in other resources infects around 50% of the human population and is asymptomatic in 70% of the cases. H.pylori eradication in childhood will not only result in peptic symptoms relief, but will also prevent late-term complications such as cancer. Today, probiotics are being increasingly studied in the treatment of gastrointestinal infections as an alternative or complement to antibiotics.
Objectives: In this study we aimed to assess the effect of S. boulardii supplementation on H.pylori eradication among children in our region.
Patients and Methods: In this randomized double-blind placebo-controlled clinical trial 28 asymptomatic primary school children with a positive H.pylori stool antigen (HpSA) exam were randomly allocated into the study group, receiving Saccharomyces Boulardii check for this species in other resources and the control group receiving placebo capsules matched by shape and size, for one month. The children were followed up weekly and were reinvestigated four to eight weeks after accomplished treatment by HpSA testing. The significance level was set at P < 0.05.
Results: 24 children completed the study. The mean HpSA reduced from 0.40 ± 0.32 to 0.21 ± 0.27 in the study group, indicating a significant difference (P = 0.005). However, such difference was not observed in the control group (P = 0.89). Moreover, the HpSA titer showed a 0.019 ± 0.19 decrease in the study group whereas the same value was 0.0048 ± 0.12 for the controls, again stating a significant difference (P = 0.01).
Conclusions: Saccharomyces boulardii has a positive effect on reducing the colonization of H.pylori in the human gastrointestinal system but is not capable of its eradication when used as single therapy.

Probiotic, Helicobacter Pylori Stool Antigen, Saccharomyces Boulardii, Helicobacter Pylori

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