Purpose:
To investigate the activity of
Feronia elephantum
fruit pulp extract (which is used in folk medicine) against
indomethacin-induced gastric ulcer in rats.
Methods:
The fruit pulp was extracted with ethanol and the anti-ulcer activity of the extract in indomethacin-induced
gastric ulceration in Swiss albino rats was evaluated. The parameters assessed were pH and acid concentration of
gastric contents, and gastric ulcer index. Ranitidine was used as the reference anti-ulcer drug. Acute toxicity studies
were also carried out.
Results:
The extract (500 mg/kg, p.o.) inhibited indomethacin-induced gastric ulceration by decreasing acid
concentration of gastric fluid while elevating its pH (p < 0.01), and compared well with the standard drug, ranitidine (p
< 0.001). However, its anti-ulcer activity was not as potent as that of ranitidine. Acute toxicity studies showed that
there was no mortality following the administration of the extract in a dose range of 250 - 5000 mg/kg, p.o..
Conclusion:
Feronia elephantum fruit pulp extract has potent antiulcer activity with low toxicity. Its anti-ulcer property
probably acts via a reduction in gastric acid secretion. The results obtained support the use of this herbal material in
folk medicine.
