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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 9, No. 4, 2010, pp. 365-371
Bioline Code: pr10043
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 9, No. 4, 2010, pp. 365-371

 en Improved production of pharmacologically-active sclerotiorin by Penicillium sclerotiorum
Lucas, Esther M.F.; Machado, Yuri; Ferreira, Alexandre A.; Dolabella, Luiza M.P. & Takahashi, Jacqueline A.


Purpose: The aim of this work was to study the optimum conditions for the production of sclerotiorin, a highly active secondary metabolite of Penicillium sclerotiorum under different cultural media.
Methods: A Brazilian strain of P. sclerotiorum was grown under different culture conditions in two liquid media (malt and a dextrose-peptone salt medium supplemented with sodium chloride) and in solid state fermentation in rice. Sclerotiorin production was monitored by high performance liquid chromatography (HPLC).
Results: Quantitative analysis of sclerotiorin content by HPLC indicated that sclerotiorin production reached the highest level (up to 313 ± 10 mg.L-1 ) in the dextrose-based medium after 10 days of fermentation. Rice and malt broth showed lower production levels.
Conclusion: Enhanced production of P. sclerotiorin for pharmaceutical development can be achieved using dextrose-based cultures.

Penicillium sclerotiorum, Sclerotiorin, Yield improvement, HPLC, Pharmaceutical industry

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