About Bioline  All Journals  Testimonials  Membership  News

Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 11, No. 5, 2012, pp. 695-702
Bioline Code: pr12082
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 5, 2012, pp. 695-702

 en Formulation and Optimization of Celecoxib-Loaded Microspheres Using Response Surface Methodology
Shahzad, MK; Ubaid, M & Murtaza, G


Purpose: To employ response surface methodology (RSM) for statistical optimization of formulation factors in the preparation of celecoxib-loaded microspheres.
Methods: Celecoxib microspheres were prepared by solvent evaporation method. Biodegradable/biocompatible polymers, Eudragit L-100 and polyvinyl pyrrolidone, were used in the encapsulation procedure. A central composite design employing Stat-Ease design Expert®, version 7.0.3 having a unit value of α was used according to reference protocols to assess the influence of two independent variables (i.e., the concentration of the two polymers used) on four dependent variables (i.e., recovery, encapsulation efficiency and % drug releasred). The polymers used were Eudragit-L100 (X1) and polyvinyl pyrrolidone (X2). The microspheres were characterized for size, shape, recovery (%), entrapment efficiency and drug release.
Results: The recovered total weight of microspheres ranged between 49.4 ± 3.1 and 91.1 ± 4.8 %, and it decreased with increase in the concentration of PVP. Entrapment efficiency was in the range of 54.1 ± 2.9 to 95.6 ± 3.7 %, and was also dependent on polymer concentration. The release of celecoxib increased with decrease in Eudragit L-100 concentration and increase in PVP concentration. Higuchi model was the best-fit drug release from all the formulations. Korsemeyer-Peppas release exponent (n) indicates that drug release pattern was non-Fickian diffusion.
Conclusion: Using RSM, it is possible to optimize the drug release properties of celecoxib-loaded microspheres. A celecoxib-loaded microsphere formulation with optimum recovery, entrapment efficiency and release behavior was proposed.

Celecoxib, Eudragit L-100, Polyvinyl pyrrolidone, Response surface methodology, Microspheres.

© Copyright 2012 - Tropical Journal of Pharmaceutical Research
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil