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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 11, No. 5, 2012, pp. 783-791
Bioline Code: pr12093
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 11, No. 5, 2012, pp. 783-791

 en Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats
Akindele, Abidemi J; Aigbe, Flora R; Olowe, Johnson A; Oduntan, Babajide O & Adeyemi, Olufunmilayo O


Purpose: DAS-77 is a phytomedicine that contains the dried bark of Mangifera indica check for this species in other resources and root of Carica papaya check for this species in other resources . This study investigated the antiulcer effects of DAS-77 in rats.
Methods: DAS-77 was administered orally twice daily for five consecutive days at doses of 50 - 400 mg/kg. Ulcer was induced in rats with ethanol, indomethacin, pylorus ligation (PL) and cold restraint stress (CRS). Ulcer scores were recorded based on examination of excised stomachs. Estimations of gastric content volume, pH and titratable acidity in the PL model and determination of the levels of antioxidants and malondialdehyde (MDA) in gastric tissues in the CRS model were also done.
Results: In all the models, DAS-77 produced significant dose-dependent reductions in ulcer score. Peak effects were produced at the dose of 400 mg/kg with ulcer inhibition values of 98.57, 76.23, 99.28 and 96.70 % compared to 100.00, 93.79, 98.92 and 96.79 % for misoprostol/cimetidine, respectively, for the ethanol, indomethacin, PL and CRS models. In the PL model, DAS-77 caused a significant increase in pH of gastric content but a reduction in volume and titratable acidity. At doses of 50 and 100 mg/kg in the CRS model, DAS-77 significantly increased the level of reduced glutathione (GSH) and diminished MDA.
Conclusion: The results obtained in this study suggest that DAS-77 possesses gastroprotective activity possibly due to reduced gastric secretion and acidity, and antioxidant activity.

DAS-77, Phytomedicine, Mangifera indica, Carica papaya, Gastroprotective effects, Ulcer.

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