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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 4, 2015, pp. 731-742
Bioline Code: pr15096
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 4, 2015, pp. 731-742

 en Cytochrome P450 from Plants: Platforms for Valuable Phytopharmaceuticals
Villa-Ruano, Nemesio; Pacheco-Hernández, Yesenia; Lozoya- Gloria, Edmundo; Castro-Juárez, Carlos Jonathan; Mosso-Gonzalez, Clemente & Ramirez-Garcia, Sergio Alberto


Cytochrome P450 enzymes are important for biotechnology due to their capacity to modify diverse secondary metabolites that may produce chemicals with pharmacological properties. Most terpenes, flavonoids and alkaloids require P450 catalytic functions to reach their biological activity. In the last ten years, several efforts have focused on the expression and production of these three main types of secondary metabolites in engineered microorganisms and plants using P450 of ethnobotanical origin. Despite this, several P450 coding sequences from plant sources are discovered yearly but only a few have been screened by functional genomics. Amongst them, only a few have shown potentials for use in sustainable production of novel drugs and highly valuable products. Cytochrome P450 involvement in the biosynthesis of these products is discussed in this work. Keywords: Biotechnological platforms, Cytochrome P450, Phytopharmaceuticals, Yield improvement, Terpenes, Flavonoids, Alkaloids, Microbial expression

Biotechnological platforms; Cytochrome P450; Phytopharmaceuticals; Yield improvement; Terpenes; Flavonoids; Alkaloids; Microbial expression

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