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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 6, 2015, pp. 1089-1094
Bioline Code: pr15143
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 6, 2015, pp. 1089-1094

 en Extended-Spectrum Beta-Lactamase (ESBL)– Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria
Ogefere, Helen O.; Aigbiremwen, Patience A. & Omoregie, Richard


Purpose: To determine the prevalence of extended spectrum beta lactamase (ESBL) producing Gram negative bacteria causing wound and urinary tract infections among in- and out-patients in a tertiary health acility.
Methods: The presence of ESBL was determined among 230 Gram negative bacilli isolated from wound (105) and urine (125) specimens from in- and out- patients who attended University of Benin Teaching Hospital (UBTH) for treatment using the double disc synergy method. Disc susceptibility test was performed on all isolates using standard techniques.
Results: There was no significant difference in the prevalence of ESBL production between isolates from wound (47.6 %) and urine (41.6 %) as well as between in - patients (48.8 %) and out – patients (39.38 %). Enterobacter check for this species in other resources species were the most prevalent producers of ESBL from both wound and urine specimens as well as from both in - and out – patients. Bacterial isolates that produced ESBL were more resistant to amoxicillin - clavulanate, ceftazidime, ceftriaxone, cefotaxime, gentamicin, ciprofloxacin and ofloxacin compared to non - ESBL producers.
Conclusion: A high prevalence (44.3%) of ESBL producing Gram – negative bacteria was observed among the patients, with Enterobacter species being the most prevalent. Prudent use of antibacterial agents is advocated to stem the tide.

Extended-spectrum beta-lactamase; Enterobacter species; Wound; Urine; Gram negative bacteria

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