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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 12, 2015, pp. 2319-2323
Bioline Code: pr15306
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 12, 2015, pp. 2319-2323

 en Genetic Polymorphisms of Osteopontin in Association with Ankylosing Spondylitis in a Chinese Population
Wang, Xiu-fang & Cai, Yi


Purpose: To determine the association of osteopontin (OPN) polymorphisms with ankylosing spondylitis (AS).
Methods: A total of 120 cases diagnosed with AS and 106 age- and sex-matched healthy controls were recruited. All the patients were human leukocyte antigen (HLA)-B27 positive. Three single nucleotide polymorphisms were genotyped using direct sequencing
Results: The T allele at -443 SNP had significantly higher frequency in AS patients (0.1875) than the controls (0.1085, p < 0.01). The rate of CT+TT genotype in AS patients was significantly higher than those with CC genotype compared with the control (p < 0.01).
Conclusion: SNP at -443 of OPN gene can serve as a candidate genetic marker to evaluate the risk of AS, thus indicating that subjects who carry T allele have a significantly higher risk of developing AS.

Genetic polymorphism; Ankylosing spondylitis; Osteopontin; Sequencing

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