Vitex doniana
is traditionally used in Togo to treat various diseases including wounds. The aim of this work was to
evaluate the efficiency of
Vitex doniana on cutaneous wound healing. Wounds were induced in ICR mice divided into four
groups as following: Group I received carbopol 974P NF empty gel, Groups II and III were treated topically with carbopol
gel containing 2.5% and 5% of
Vitex doniana extract. Group IV received Betadine® 10% as standard drug. The efficacy of
treatment was evaluated by planimetry and histological analysis. We secondary used the gel containing
Vitex doniana at
2.5% and the pure extract at 10 mg/ml on the model of ear edema induced by xylene. Skin toxicity test was performed with
the gel containing
Vitex doniana at 5% and the pure extract at 30 mg/ml.
Vitex doniana at 5% and 2.5% provided better
wound contraction (91.14% and 86.38%) at day 12 post-excision when compared to control (51.15%). The results of
histological evaluation supported the outcome of excision wound model. Moreover
Vitex doniana inhibited significantly
edema induced by xylene when compared to control (p< 0.05). In skin toxicity test, no abnormal symptoms were developed
over 14 day-time period.
Vitex doniana inhibits the topical inflammation and accelerate cutaneous wound repair.
