Background: Melastoma malabathricum
L. Smith (family Melastomaceae) is a shrub that has been used by the Malay practitioners of
traditional medicine to treat various types of ailments. The present study aimed to determine the chemopreventive activity of methanol extract
of M. malabathricum leaves (MEMM) using the standard 7,12-dimethylbenz(α)anthracene (DMBA)/croton oil-induced mouse skin
carcinogenesis model.
Materials and Methods: In the initiation phase, the mice received a single dose of 100μl/100 μg DMBA (group I-V) or 100μl acetone
(group VI) topically on the dorsal shaved skin area followed by the promotion phase involving treatment with the respective test solutions
(100 μl of acetone, 10 mg/kg curcumin or MEMM (30, 100 and 300mg/kg)) for 30 min followed by the topical application of tumour
promoter (100μl croton oil). Tumors were examined weekly and the experiment lasted for 15 weeks.
Results: MEMM and curcumin
significantly (p<0.05) reduced the tumour burden, tumour incidence and tumour volume, which were further supported by the
histopathological findings.
Conclusion: MEMM demonstrated chemoprevention possibly via its antioxidant and anti-inflammatory activities, and the action of
flavonoids like quercitrin.