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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 14, No. 5, 2017, pp. 138-146
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Bioline Code: tc17067
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Traditional, Complementary and Alternative Medicines, Vol. 14, No. 5, 2017, pp. 138-146
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POSSIBLE CARDIOPROTECTIVE ACTION OF POMEGRANATE JUICE PUNICA GRANATUM AND PROPOLIS AGAINST MYOCARDIAL INFARCTION INDUCED IN RATS.
Aloutaibi, Ghadeer Turki; Gashlan, Hanaa; Moselhy, Said Salama; Malki, Abdulrahman L. Al- & Khan, Jehan A.
Abstract
Background: The present study was conducted to evaluate the protective role of pomegranate juice alone or in
combination with propolis extract against isoproterenol (ISO) induced myocardial infarction in rats.
Material and Methods: Male Wister albino rats (n=60) weighing 220-280g were divided into six groups each group
contain ten rats; group I: negative control fed standard diet. Group (II-VI): Rats were injected subcutaneously with
isoproterenol (150 mg/kg) for 3 days. Group III: Rats were given pomegranate juice 1ml /rat / day. Group IV: Rats
were given propolis extract (50 mg/kg BW). Group V: Rats were given pomegranate juice + propolis extract. Group
VI: Rats were given glyceronitrate (2.6mg/kg.bw/day).
Results: The ISO-induced myocardial infarction in untreated rats has indicated by significant (p < 0.001) elevation of
cardiac marker enzymes such as aspartate aminotransferase (AST), Lactate dehydrogenase (LDH), creatine kinase
(CK), and cardiac troponin I (CnI ) when compared with control group. Rats treated with pomegranate juice and
propolis extracts showed highly significant (p<0.001) improvement in cardiac marker enzymes activities when
compared with untreated myocardial infarction group. Histological investigation showed features of damaged muscles
(atrophy, necrosis) which while it was ameliorated in treated groups with superior effect with pomegranate juice.
Conclusion: It was concluded that, pomegranate juice in combination with propolis have a potential to alleviate the
oxidative stress that induce myocardial infarction and therefore reduce the incidence of cardiovascular diseases.
Keywords
Pomegranate juice; Propolis; Myocardial infarction; Rats.
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